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Research Progress on the GIP/GLP-1 Receptor Coagonist Tirzepatide, a Rising Star in Type 2 Diabetes - PMC

In animal studies, GLP1-agonists were associated with reduced fetal weight and/or growth, delayed ossification and skeletal variants, usually associated with a reduction in maternal weight gain and decreased food consumption

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For comparison, the improvement in glycemic control following bariatric surgery is of the same order, with a decrease in A1c varying between 1.8 and 3.5%